European Journal of Anatomy

Official Journal of The Spanish Society of Anatomy
Cover Volume 24 - Number 5
Eur J Anat, 24 (5): 381-389 (2020)

Protective efficacy of Allium jesdianum on liver parameters, inflammatory cytokines, oxidative injury and apoptotic changes in mercuric chloride-induced hepatotoxicity in rats

Cyrus Jalili1, Navid Golshani2, Yadollah Bahrami3, Shiva Roshankhah4, Mohammad Reza Salahshoor4

1Department of Anatomical Sciences, Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran, 2Department of Anatomical Sciences, Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran, 3Department of Medical Biotechnology, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran, 4Department of Anatomical Sciences, Medical School, Kermanshah Universi-ty of Medical Sciences, Kermanshah, Iran

ABSTRACT Mercuric chloride (MC) is a chemical compound made from a combination of mercury and chlorine causing intracellular oxidative stress generation. Allium jesdianum (AJ), as a member of the Liliace-ae family, has various pharmacological and strong antioxidant properties. This study aimed to evalu-ate the probable therapeutic effects of AJ against hepatocytes degeneration, inflammation, apoptotic changes and oxidative injuries induced by MC ad-ministration. Sixty-four rats were randomly divided in eight groups (n = 8) including groups of control, MC (50 mg/kg), AJ (500, 1000, 2000 μg/ml), and MC+AJ. They were intraperitoneally and orally ad-ministrated for one week. Nitrite oxide, lipid peroxi-dation (LP) levels, and Ferric Reducing Ability ofPlasma (FRAP) assays were conducted to evalu-ate the intracellular antioxidant index.

Keywords: Allium Jesdianum ?? Mercuric chloride ?? Oxidative ?? Apoptosis ?? Hepatotoxicity ?? Inflammation

European Journal of anatomy
ISSN 2340-311X (Online)