Diabetes is an increasing health problem that could increase the rate of congenital malformations. Therefore, the burden on health care providers and society is increasing, which could be mitigated by providing treatments that are based on natural, available, and cheap materials. One of the natural hypoglycemic treatments that had been used is Corn Silk aqueous extract (CSE). One of the targeted beneficiaries from these treatments are diabetic pregnant women. The aim is to study the teratogenicity of CSE, as well as whether it reduces the effect of hyperglycemia on the offspring. Female mice were divided into four groups: Control, Treated, Diabetic Control, and Diabetic Treated. Pregnant mice of treated groups were given a daily dose of 4 g/kg of CSE orally, while control mice were given equal amounts of distilled water. Samples were collected on day 16.5 of pregnancy, birth (neonates), and 3 weeks postnatal. Whole body weight, length, and morphological malformations were recorded. The most frequent malformation observed was Intrauterine Growth Retardation (IUGR) among the diabetic groups’ samples. The rate of malformations in fetuses of diabetic mothers was not decreased, but in 3-week-old mice of treated mothers we observed a significant increase in whole body weight and length. We concluded that CSE consumption during pregnancy might not be favorable in the dose used, while it might have some benefits if used while nursing. More studies with different doses and their frequencies are needed. Also, the effect of the extract on lactation and nursing milk composition should be investigated.
Dema Alsudairi, Fatma Al-Qudsi
Biological sciences department, science faculty, King Abdulaziz University
Eur. J. Anat.
ISSN 2340-311X (Online)