Diabetes mellitus is becoming a serious health challenge to many individuals all over the world. The treatment and management of diabetes is geared towards keeping blood glucose levels as closely related as possible to that in healthy individuals. Medications used to treat diabetes are usually associated with complications and may cause different side effects, in addition to being unavailable in some rural areas. Many traditional anti-diabetic plants have become popular in the management of diabetes mellitus in such instances, and Leptadenia hastata has been used as locally as treatment for diabetes. The present study aimed at evaluating the effect of n-hexane extract of Leptadenia hastata on the histology of the liver in streptozotocin (STZ)-induced diabetic rats.
Diabetes mellitus was induced in 20 Wistar rats using a single injection of streptozotocin (50 mg/kg i.p.). The rats were divided into four groups of 5 rats each. Group III were untreated diabetic rats, Group IV and V were administered with 100mg/kg and 200mg/kg of the extract respectively, group VI was treated with insulin (6IU/kg) Groups I and II were non-diabetic rats. Group I rats were treated with olive oil and group II rats were treated with 200mg/kg of the extract for 28 days. Histological observation revealed dilation of central veins, degeneration of hepatocytes, and reduced glycogen granules in the untreated diabetic group. These pathological changes were ameliorated in the Leptadenia hastata extract and insulin-treated rats. Leptadenia hastata extract may represent an alternative treatment to control diabetes mellitus and its associated hepatopathy.https://eurjanat.com/download/853/