European Journal of Anatomy

Official Journal of The Spanish Society of Anatomy
Cover Volume 16 - Number 2
Eur J Anat, 16 (2): 127-133 (2012)

Analytical view of the simultaneous occurrence of sacralisation and congenital anomalies

Rajani Singh

Department of Anatomy, CSM Medical University, Lucknow, UP, India

ABSTRACT The modulated mutations of the HOX11and PAX1/9 families cause defective sacralisation with associated congenital anomalies in organs such as the hindlimb, forelimb, thymus, parathyroid etc in mice. Thus, an attempt has been made to extend the study of the sacralisation of dry human sacra with associated anomalies in human beings analogous to mice by conceiving a hypothesis to be established by future research. The objective of the present study is to facilitate for clinicians the management and treatment of sacralisation-related diseases along with associated anomalies extracted from mice and extended to humans. Sixty-six classified sacralised dry human sacra were examined at the osteology laboratory of CSM Medical University Lucknow, UP, India. These sacra were genetically analysed to establish the relationship between sacralisation and associated anomalies analogous to those found in mice. The combined effect of mutation of HOX11and PAX1/9 gene expression causes several types of sacralisation with associated anomalies in human beings that are similar to those in mice. Sacralisation in humans may be accompanied by particular associated anomaly alerting clinicians. The study may revolutionize clinical practice and diagnosis.

Keywords: Sacralisation, Genes, Coccygeal vertebra, Sacrum

European Journal of anatomy
ISSN 2340-311X (Online)