The aim of this study is to establish age and sex based-reference values of corpus callosum (CC) length and its distancesto the fornix and anterior commissure. Brain MRIs of 214 subjects, who had normal MRI scans according to radiologists’reports, were reviewed retrospectively. Scans were obtained from April 2013 until April 2014 at Jordan UniversityHospital, Radiology Department (Amman, Jordan). The antero-posterior (longitudinal) dimensions of the CC (AB), the vertical distance between the anterior commissure and the most superior point of CC (CD), the distance between the genuand the fornix (AE), and the angle between AB (the longitudinal dimension of the CC) and AD (the distance from the genu to the anterior edge of the anterior commissure) (BAD) were measured and subjected to statistical analysis.Regardless of sex, CC length and other parameters (CD and AE) increased dramatically with age in children andadolescents (≤ 18years). A significant negative correlation was found between age and BAD angle in females only. Weobserved a continuous increase in CC length after childhood in both sexes, with a slower rate of growth in females.Sexual dimorphism was observed in AB and BAD angle in infants (≤ 2years) and AE in the adolescent group (12 to 18years old). A local reference of CC length and its distances to nearby structures were established. Sexual dimorphisms of some CC parameters were more evident during the early years of life. Our data also indicated important sex differences in the development of the CC. Such knowledge is essential in evaluating the normal neurological development of the CC and the pathological conditions affecting it.
Maher T. Al-Hadidi1, Heba M. Kalbouneh2, Ashraf Ramzy3, Aiman Al Sharei3, Darwish H. Badran2,3, Amjad Shatarat2, Emad S. Tarawneh4, Waleed S. Mahafza4, Fadi A. Al-Hadidi5, Azmy M. Hadidy3
1 Department of Anatomy and Histology, Faculty of Medicine, Al-Balqa Applied University, Al Salt, Jordan.
2 Department of Anatomy and Histology, School of Medicine, The University of Jordan, Al Salt, Jordan.
3 Department of Basic Medical Sciences, School of Medicine, The Hashemite University, Zarqa, Jordan.
4 Department of Diagnostic Radiology and Nuclear Medicine, School of Medicine, The University of Jordan, Amman, Jordan.
5 Department of Special Surgery, School of Medicine, The University of Jordan, Amman, Jordan