Effects of MSG on the lymph nodes of the albino rat: Ultrastructural and morphometric studies

The purpose of the study was to study the morphometric and electron microscopic changes of the parenchyma of the mesenteric lymph nodes of rats under the conditions of action of monosodium glutamate and its abolition. The paper presents and analyzes data from an experimental study conducted on 76 albino rats in females and males of reproductive age. Experimental animals are divided into 5 groups. Eight weeks of exposure to monosodium glutamate (MSG) showed a significant decrease in the relative area of the cortical substance in the parenchyma of the mesenteric lymph nodes of albino rats in males and females by 10.3% and 8.3%, respectively, and an increase in the relative area of the medullary substance by 16.1% and 13.2%, respectively with an intact group of animals. Submicroscopically after eight weeks of exposure to monosodium glutamate, as well as after eight weeks of cancellations, in the parenchyma of lymph nodesintercellular spaces are enlarged, lymphocytes have low electron density, karyolysis, organelles at different stages of decay, the number of macrophages increases, cellular detritus and osmiophilic inclusions in the cytoplasm of macrophages and in the intercellular space. The wall of arterioles is thickened, sclerosed, nuclei of large endothelial cells. There are thorough defects in the capillary wall, venous plethora. The hemocapillary lumen is narrowed due to numerous protrusions and microvilli of the cytolema of endothelial cells. Changes appear after two weeks of action of monosodium glutamate and increase by the eighth week of the experiment. Any changes will not return to normal after cancellation of exposure to monosodium glutamate.