TY  - JOUR
A1  - ,  
T1  - Testosterone enhances the NADPH-diaphorase staining in the paraventricular nucleus of the hypothalamus
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 1998
VL  - 2
SP  - 159
EP  - 165
UR  - http://www.eurjanat.com/web/paper.php?id=98030004
KW  - Testosterone    - Nitric oxide  synthase
- Hypothalamus    - Neuroendocrine     - Rat.

N2  - SUMMARYNitric oxide   is  involved    in  mechanisms     which underlie   neuroendocrine       events    in   reproduc­ tion.   Since    gonadal     steroids     have    profound effects on  reproductive     function,   it is of  interest ro examine   whether    nitric  oxide   synthase    acti­ vity is altered   by  gonadal    steroid   hormones    in specific nuclei  of the  hypothalamus.     In the  para­ ventricular   nucleus   of  the  hypothalarnus,     chan­ ges of nitric  oxide   synthase/NAOPH-diaphorase staining   have    been    shown    to   occur    after   an important   number    of  experimental     conditions. Basecl on   previous    studies    demonstrating      that NAOPH-diaphorase    activity  in the  paraventricu­ lar nucleus   of  the   hypothalamus      is  modulated by estradiol,   a  possible    anclrogen    influence    on this  activity   was   ínvestígated     in  the   neuronal populations    (magno-    and   parvicellular)     of  this nucleus.  Cryostat   sections   were   cut  and  proces­ sed   for   the    histochemícal      cletection     of   the NAOPH-cliaphorase     activity.    Following     orchi-"dectomy   (14  days),   numerical    data  displayed    adecrease    in   the   number     of   NAOPH-neurons, especially   in   the   posterior     magnocellular      and the medial  parvicellular    subdívisions    (p  < 0.05), which  was   reversed    after  daily   treatrnent    with testosterone.    These   data   indica te  that    paraven­ tricular NAOPH-diaphorase     neurons    are  influen­ ced by  testosterone.
ER  -