TY  - JOUR
A1  - ,  
T1  - Subdivisions of the human substantia nigra using AChE histochemistry
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 1998
VL  - 2
SP  - 115
EP  - 122
UR  - http://www.eurjanat.com/web/paper.php?id=98020012
KW  - Acetylcholinesterase       -   substantia nigra  - human   - hístochernístry    - basal  ganglia
N2  - The   present   work   describes    the  neurochernical activity   detected    in  the   nigral   complex    of  the adult  human   using  the acetylcholinesterase     histo­ chemical   technique.    Such  activity  is seen   at cell level  in the  pigmented    neurons   of the  pars  com­ pacta   of  the   substantia    nigra,   and,   to  a  lesser degree,   in the  paranigral   neuronal    groups   (ven­ tral tegmental   area  and  retrorubral   field).  There  is also  considerable     enzymatic   activity  in the  neu­ ropil  of  the  substantia    nigra.  However,   the  pars lateralis  and  overall   the  ventromedial    portion   of the   substantia     nigra    present    a   relativeJy   low acetylcholinesterase      content,    though    both   have so me   acetylcholinesterasic      neuronal     bodies.    A series   of  studies    in  different   species   suggested that   in  the   substantia     nigra,   AChE  is  released almost  exdusively    from  dopaminergic    nígrostria­ tal  neurons    and   precisely   from   their  dendrites, which  protrude   widely   into  de  pars  reticulata.   In addition,   previous   findings   made   in the  cat  and in the  monkey   reported   a direct  correlation   bet­ ween   nigral  AChE  activity  and  nigrostriatal   con­ nections.   The  non-uniform    distribution    of  AChE activity  within   the  human   nigral  complex   repor­ ted  here   may  indicate   the  modular   organization of  the  intrinsic   neurons    of  the  substantia    nigra and  their  mesostriatal   projections.
ER  -