TY  - JOUR
A1  - ,  
T1  - NADPH-diaphorase activity in the paraventricular nucleus of the hypothalamus: distribution, coexiztence and functional implications
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 1998
VL  - 2
SP  - 35
EP  - 43
UR  - http://www.eurjanat.com/web/paper.php?id=98010019
KW  - Nitric  oxide  synthase  - Coexisience   -
Magnocellular      - Parvocellular      - Mecliocellular.

N2  - In  mammals   neurons     of  the  hypothalamíc       para­ ventricular   nucleus   exhibir    intense   and   selecrive sraining   (mainly    magnocellular     component)     for NAOPH-diaphorase.    Several    coexistcnces    of   this enzyme with  neurobiological    substances     and   func­ tional  implications    have  been   reponed.    Additio­ nally, different   experimental   conditions     such as salt loading,       food      deprívatíon,         stress,    lactation, hypophysectomy   and  hormonal   treatments  promo­ te changes  in  the  expression   of  rhe enzyrne  in the paraventricular      nucleus.   In  the   present    paper   xve analyze   the  inforrnation     available    about    the  distri­ bution   of  NADPH-diaphorase    activity   in  the   para­ ventricular    nucleus,  the   coexistence   with   different bioactive     molecules    and    its   possible      functional roles. \Xfe condude    that   1.- There  is a wiclespread expression   of    TADPH-cliaphorase   activiry   in  the thrce   different   rypes   of   neurons   located   in  rhe paraventricular      nucleus     (magno-,     parvo-    anclmediocellular  (mes). However,  the highest  concen­p'alion of  the  neurons  showing   this  activiry   is situa­red  at  the   level   of  the  magnocellular   component.2.- These  NADPI-l-diaphorase    neurons   co-express neuropeptides    and   other   neuroactive   substances, although   there   is  not  él   general   correspondence with   a specific   onc  suggesting   that      AOPH-cliap­ horase is not  relared  to general  mechanisms   invol­ ving  rhese subsiances.   3.- NADPH-diaphorase    acti­ vity   in    rhe    paraventricular       nucleus     can    be modulatcd   hy  differenr  hormones   and  experimen­tal conditions.   4.- Basccl upon  rhe foregoíng, nitricoxide   proclucing    neurons   in  the   paraventricular nucleus  are an irnportant  cellular  population   of rhis nucleus   involved    in  multiple    mechanisms,   espe­ cially    neuroendoerine      funcrions.    However,     the exacr role  of  rhis messcnger  molecule   in rhe para­ ventricular   nuclcus  is not  torally  known.
ER  -