TY  - JOUR
A1  - ,  
T1  - Distribution of the a<sub>1</sub>, a<sub>2</sub> and B<sub>2/3</sub> GABA<sub>A</sub> receptor subunits in the anterior thalamus of the rat
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 1997
VL  - 1
SP  - 43
EP  - 50
UR  - http://www.eurjanat.com/web/paper.php?id=96010046
KW  - Thalamus
KW  - GABAA receptor
KW  - immunocytochemistry
KW  - rat.

N2  - The distribution of the al' a2 and ~2/3subunits of the GABAA receptor in the anterior thalamus of the rat was studied by immunocytochemistry using subunit-specific antibodies. In general, though with some exceptions, immunoreactivity was observed    mostly  in the  neuropil.   Most  prin­ cipal (relay) thalamic nuclei showed strong al and ~2/3-positivity; however, most intralaminar nuclei  were immunonegative for these subunits. The reverse was true of a? immunoreactivity: most  intralaminar nuclei were strongly a?-positive, whereas   most  principal   nuclei  were  cl?-nega­ tive  or only  weakly   immunopositive.     These  data suggest    that   neurons     in   the   principal     nuclei mostly  express   GABAA receptors    containing    the aland    ~2!  subunits    (i.e.  benzodiazepine      type   1 receptors),    while  neurons   in the  intralaminar    nu­ clei  mostly  express   GABAA receptors   containing the  a?  subunit    (i.e.   benzodiazepine      type   II re­ ceptors).    Double-Iabeling     experiments     revealed colocalization     of the  al  and  ~2/3 subunits insomata and neurites of most principal nuclei. Colocalization of the al and a2 subunits was observed only in neurons of the anterodorsal nucleus.
ER  -