TY - JOUR A1 - , T1 - Distribution of zinc iodide-osmium positive dendritic cells in the human appendix JO - Eur. J. Anat. SN - 1136-4890 Y1 - 2006 VL - 10 SP - 15 EP - 20 UR - http://www.eurjanat.com/web/paper.php?id=06010015 KW - iodine derivative KW - osmium derivative KW - unclassified drug KW - zinc derivative KW - zinc iodide osmium KW - adult KW - appendix KW - article KW - cell count KW - cell size KW - cell type KW - cellular distribution KW - complex formation KW - controlled study KW - dendritic cell KW - female KW - follicular dendritic cell KW - germinal center KW - human KW - human tissue KW - immune response KW - lymph follicle N2 - Dendritic cells are antigen-presenting cells found in almost every type of tissue, including lymphatic tissue, blood and skin. In the intestinal tract, these cells are likely to play a pivotal role in the initiation and regulation of immune responses. Our earlier study of the human colon and ileum revealed the presence of zinc iodide-osmium-positive dendritic cells. In the present study we demonstrate the presence of ZIO-positive dendritic cells in the human appendix. ZIO-positive cells were seen in the region of crypts of Lieberk├╝hn as well as in the surface epithelium. The cells showed a single long process directed towards the lumen. They were long, slender, and triangular. In the region of the lymphoid follicle, two different types of dendritic cells were noted. The follicular dendritic cells present in the germinal center were few in number, larger in size and with thick dendritic processes. However, in the mantle zone typical dendritic cells were seen. They were smaller in size and had many thin processes. The distribution of dendritic cells in the human appendix confirms the role of the appendix in the immune response. ER -