TY  - JOUR
A1  - ,  
T1  - Leptin in adipose tissue - Morphological aspects
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 2004
VL  - 8
SP  - 95
EP  - 99
UR  - http://www.eurjanat.com/web/paper.php?id=04020095
KW  - leptin
KW  - peptide hormone
KW  - adipose tissue
KW  - gene
KW  - human
KW  - intracellular transport
KW  - pathophysiology
KW  - protein expression
KW  - protein function
KW  - protein localization
KW  - protein secretion
KW  - protein structure
KW  - protein synthesis
KW  - protein transport
KW  - review
KW  - ultrastructure
N2  - Leptin is a peptide hormone encoded by the obgene and released by adipocytes. Over the past few years, the synthesis, regulation and effects of leptin have been extensively investigated in view of its pleiotropic role in human (patho)physiology. This work aimed at reviewing current morphological knowledge on leptin synthesis and secretion in adipocytes. It is concluded that the intracellular trafficking of leptin and the structural basis of leptin secretion remain to be defined. Further morphological work, especially at the ultrastructural level, is needed to firmly establish the intracellular distribution and the release pathways of the hormone.
ER  -