TY  - JOUR
A1  - ,  
T1  - The development of the palate - A brief review
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 2003
VL  - 7
SP  - 53
EP  - 74
UR  - http://www.eurjanat.com/web/paper.php?id=03S10053
KW  - collagen type 9
KW  - Hermes antigen
KW  - hyaluronic acid
KW  - transforming growth factor
KW  - apoptosis
KW  - cell maturation
KW  - cell migration
KW  - cell proliferation
KW  - collagen synthesis
KW  - epithelium cell
KW  - extracellular matrix
KW  - Golgi complex
KW  - homeobox
KW  - human
KW  - mesenchyme
KW  - organogenesis
KW  - palate
KW  - short survey
N2  - Palatogenesis is a complex developmental process that requires two main events: elevation and then fusion of the palatal shelves. There remains controversy concerning the mechanism(s) responsible for palatal shelf elevation, it being proposed that an intrinsic shelf elevation force might be produced either by the generation of a turgor pressure following hydration of the extracellular matrix via its glycoconjugate molecules or by proliferation, migration and/or contraction of the palatal shelf mesenchymal cells. Recent evidence indicates that the shelf elevation force is related to the presence of hyaluronan in the extracellular matrix, to an as yet unknown molecule that is packaged in the mesenchymal cells' Golgi complex, and to CD44 receptor functioning. For fusion of the palatal shelves to occur, the breakdown of the midline epithelial seam relates to apoptosis and redifferentiation of the epithelial cells and this appears to be signalled by the synthesis of type IX collagen just prior to the breakdown of the basement membrane around the midline epithelial seam. The events associated with palatogenesis are controlled by the palatal shelf mesenchyme, under the influence of a variety of homeobox genes and transcription factors and and of several growth factors (particularly TGF-?s).
ER  -