European Journal of Anatomy

Official Journal of The Spanish Society of Anatomy
Cover Volume 24 - Number 5
Eur J Anat, 24 (5): 391-397 (2020)

The effect of regulatory aerobic exercise on lipoproteins index of plasma in epileptic male rat

Seyed Mehdi Beheshti-Nasr1, Amir Raoofi2, Rahim Golmohammadi2

1Instructor Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran, 2Cellular and Molecular Research Center, Department of Anatomy, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

ABSTRACT There is no report on the evaluation aerobic ex-ercise on lipoproteins and Atherogenic Index of Plasma (AIP) in epileptic male rats. In the present study our purpose was to elucidate the effect of regulatory aerobic exercise on Lipoproteins and (AIP) in epileptic male rat by pentylentetrazol. In this experimental study, 40 male rats randomly divided into 2 main different epileptic (kindling) and non-epileptic groups (n=20). The epileptic groups were kindled by intraperitoneal injection of 40 mg/kg pentylentetrazol (PTZ), then divided into two epileptic subgroups, including the aerobic exercise and without exercise. The non-epileptic groups were divided into two subgroups including aerobic exercise and without exercise. After 6-week exer-cise rats were deep anesthetized by ketamine, and then blood was taken. Data were analyzed by t-test and ANOVA.The epileptic male rats that received aerobic ex-ercise increased significantly the seizure of param-eters S2L and S4L, compared with the epileptic group that did not receive regular exercise P<0.05. Also, in the aerobic exercise groups decreased the parameters S5D and SD compared with the con-trol group P<0.001. The exercise significantly de-creased total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDLP) as comparedwith the epileptic group without exercise P<0.001. The present study indicates that the aerobic regu-larly exercise not only decreased the duration of seizures, but also reduce the vascular risk factor in epileptic group rats.

Keywords: Aerobic exercise Lipoproteins Pentylentetrazol Rats Epilepsy

European Journal of anatomy
ISSN 2340-311X (Online)