European Journal of Anatomy

Official Journal of The Spanish Society of Anatomy
Cover Volume 17 - Number 2
Eur J Anat, 17 (2): 123-126 (2013)

Zaltoprofen induces histological changes in albino rat liver

Ramanathan Shalini, Salem S. Rajasekar and Kazhumaram V.P. Suriyakumari

Department of Anatomy, Sri Manakula Vinayagar Medical College and Hospital, Kalitheerthalkuppam, Madagadipet, Puducherry, India

ABSTRACT Hepatic injury associated with nonsteroidal anti-inflammatory drugs (NSAIDs) was found to be variable ranging from mild cholestasis to severe hepatocellular injury. Zaltoprofen is a NSAID used commonly as an analgesic in the treatment of painful disorders. The aim of this study was to determine the histological changes in the liver of albino rats after varying periods of oral zaltoprofen administration. Thirty-six adult male albino Wistar rats and the drug zaltoprofen at a dose of 40 mg/kg were employed, and 10% dimethyl sulphoxide was used as the solvent for the drug. Groups A1, B1 and C1 - each comprising 6 rats served as control groups and were treated with 10% dimethyl sulphoxide, orally via an oro-gastric tube, for 7, 14 and 21 days respectively. Groups A2, B2 and C2 - each comprising 6 rats served as experimental groups and were treated with the drug zaltoprofen dissolved in 10% dimethyl sulphoxide orally via an oro-gastric tube, for 7, 14 and 21 days respectively. Blood samples were collected from the tail vein of rats for analysis of serum alanine transaminase and serum aspartate transaminase before the sacrifice. The rats were sacrificed 24 hours after the last dose of drug and their liver was collected. The histological changes noted at the end of 7 days of zaltoprofen administration were central vein dilatation and congestion, periportal lymphocytic infiltration, and necrosis in the peripheral region. After 14 days of drug administration, there was extensive necrosis up to the central region. At the end of 21 days of drug administration, there was dilation of bile ducts as well. There was a significant increase in the levels of serum alanine transaminase at the end of 14 and 21 days. Zaltoprofen should be used cautiously in patients with liver diseases.

Keywords: NSAIDs, Zaltoprofen, Liver histology, Necrosis, Central vein

European Journal of anatomy
ISSN 2340-311X (Online)