TY  - JOUR
A1  - ,  
T1  - Tanycytes in the human median eminence contain intestinal trefoil factor (hITF)
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 1999
VL  - 3
SP  - 111
EP  - 114
UR  - http://www.eurjanat.com/web/paper.php?id=99020111
KW  - intestinal trefoil factor
KW  - neuropeptide
KW  - adenohypophysis
KW  - article
KW  - cell interaction
KW  - choroid plexus
KW  - glia
KW  - human
KW  - human tissue
KW  - immunocytochemistry
KW  - median eminence
KW  - neurosecretory cell
KW  - protein localization
KW  - tanycyte
N2  - Human intestinal trefoil factor (hITF) has been localized in hypothalamic neuroendocrine cells, the adenohypophysis and the choroid plexus, indicating that hITF may represent a novel neuropeptide involved in various neural functions. In the present study, employing combined immunocytochemistry for hITF and with immunofluorescence for glial acidic fibrillary protein GFAP, we observed that a fraction of tanycytes in the human median eminence contain hITF. It is likely that hITF is of importance for the dynamics of blood-brain barrier functions, which are known to modulate neurosecretion in the neurohypophysial and the adenohypophysial tract within the median eminence.
ER  -