TY - JOUR A1 - , T1 - Microscopic study of the rat pancreas after denervation JO - Eur. J. Anat. SN - 1136-4890 Y1 - 2020 VL - 24 SP - 1 EP - 7 UR - http://www.eurjanat.com/web/paper.php?id=190382ma KW - Rat pancreas Truncal vagotomy Sympathectomy Enteric plexus Microscopic study N2 - The aim of this study is to demonstrate that the denervation of the pancreas may affect the enteric neuronal plexus, which controls both the endocrine and exocrine parts of the pancreas. By using the light microscope, the histological changes of the islets of Langerhans and the pancreatic acini in the rat pancreas were studied two and three weeks after sympathectomy and truncal vagotomy. More-over, measurements of the changes in fasting blood glucose levels and glucose tolerance tests in the control and experimental animals were record-ed.Atrophic changes and degeneration of the pan-creatic acinar cells and islets of Langerhans cells were observed after both sympathectomy and va-gotomy. Biochemical measurements of fasting blood, and the glucose tolerance tests after sym-pathectomy and vagotomy were increased signifi-cantly, which is consistent with the histological re-sults. The results of this study explain that the exo-crine and endocrine parts of the pancreas are de-pendent on both sympathetic and parasympathetic innervation via the enteric plexuses of the rat pan-creas. These results establish a firm correlation between the autonomic innervation and the enteric plexus, which controls the function of the endo-crine and exocrine parts of the pancreas. ER -