TY - JOUR A1 - , T1 - Histochemical and morphometric evidences of the curative role of aqueous zest extract of Citrus sinensis on anti-neoplastic drug-induced testicular degeneration in animal models JO - Eur. J. Anat. SN - 1136-4890 Y1 - 2018 VL - 22 SP - 497 EP - 507 UR - http://www.eurjanat.com/web/paper.php?id=180212ga KW - Citrus sinensis peel Cisplatin Testes Oxidative stress Immunohistochemistry Infertility N2 - This study examined the curative effects of aqueous zest extract of Citrus sinensis and Cisplatin (CIS)-induced testicular degeneration. Sixteen male Wistar rats (10 to 12 weeks old) weighing 306-238 g were used in this study. The animals were divided as follows: Group A was treated orally with 2.5 ml/kg body weight/daily; Group B was treated with a single dose of 10 mg/kg body weight; Group C and D rats were given a single dose of 10 mg/kg body weight of cisplatin and then treated orally with 10 and 40 mg/kg body weight of aqueous zest extract of Citrus sinensis. The procedure lasted for 8 weeks.Results showed a significant (p< 0.05) decrease in final body weight, testis weight, testis weight/body weight ratio, normal sperm morphology (p<0.01) and a significant decrease in tubular diameter (p > 0.01), perimeter (p > 0.01 and) and length (p > 0.001), width (p >0.05) and increase (p > 0.05), germinal epithelia height, cross-sectional area, number of profiles per unit area and numerical density of seminiferous tubules. Rats that were treated with CIS alone without pre-treatment or post-treatment with extract showed marked degeneration and atrophied seminiferous tubules with absence of late stage germ cells. There was also a reduction in PAS-positive materials of the rats treated with Cisplatin. These parameters were however ameliorated in the groups that were post-treated with the aqueous zest extract of Citrus sinensis. This could have been as a result of its antioxidant and free radical scavenging potentials. ER -