TY  - JOUR
A1  - ,  
T1  - Distribution of zinc iodide-osmium positive dendritic cells in the human appendix
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 2006
VL  - 10
SP  - 15
EP  - 20
UR  - http://www.eurjanat.com/web/paper.php?id=06010015
KW  - iodine derivative
KW  - osmium derivative
KW  - unclassified drug
KW  - zinc derivative
KW  - zinc iodide osmium
KW  - adult
KW  - appendix
KW  - article
KW  - cell count
KW  - cell size
KW  - cell type
KW  - cellular distribution
KW  - complex formation
KW  - controlled study
KW  - dendritic cell
KW  - female
KW  - follicular dendritic cell
KW  - germinal center
KW  - human
KW  - human tissue
KW  - immune response
KW  - lymph follicle
N2  - Dendritic cells are antigen-presenting cells found in almost every type of tissue, including lymphatic tissue, blood and skin. In the intestinal tract, these cells are likely to play a pivotal role in the initiation and regulation of immune responses. Our earlier study of the human colon and ileum revealed the presence of zinc iodide-osmium-positive dendritic cells. In the present study we demonstrate the presence of ZIO-positive dendritic cells in the human appendix. ZIO-positive cells were seen in the region of crypts of Lieberkühn as well as in the surface epithelium. The cells showed a single long process directed towards the lumen. They were long, slender, and triangular. In the region of the lymphoid follicle, two different types of dendritic cells were noted. The follicular dendritic cells present in the germinal center were few in number, larger in size and with thick dendritic processes. However, in the mantle zone typical dendritic cells were seen. They were smaller in size and had many thin processes. The distribution of dendritic cells in the human appendix confirms the role of the appendix in the immune response.
ER  -