TY  - JOUR
A1  - ,  
T1  - The coronary circulation of the pig heart: Comparison with the human heart
JO  - Eur. J. Anat.
SN  - 1136-4890
Y1  - 2005
VL  - 9
SP  - 67
EP  - 87
UR  - http://www.eurjanat.com/web/paper.php?id=05020067
KW  - anatomical variation
KW  - angiology
KW  - animal tissue
KW  - article
KW  - coronary artery blood flow
KW  - coronary blood vessel
KW  - cytoarchitecture
KW  - electron microscopy
KW  - graft rejection
KW  - heart transplantation
KW  - histology
KW  - human
KW  - human tissue
KW  - human versus animal comparison
KW  - nonhuman
KW  - organ donor
KW  - swine
KW  - xenotransplantation
N2  - Over the last decades, the pig has been chosen as a feasible animal organ donor for the human species, namely regarding heart transplantation. This has led to the development of transgenic pigs with the goal of avoiding the rejection caused by xenotransplantation. It is therefore pertinent to characterize in detail the vascular anatomy of the pig heart and compare it with that of humans. In this study, 23 hearts from domestic pigs were subjected to two different anatomical techniques (resin vascular casting and injection/dissection with contrast suspension) in order to visualize their coronary circulation. After defining the arterial distribution and anastomoses of the branches of the coronary arteries of the pig, these features were compared with well-established descriptions of the coronary circulation in human hearts. The main contributions of this work are: (i) new features of the coronary vessels of the pig heart are documented; (ii) there is close resemblance in the architecture of the coronary arteries between the pig and humans; (iii) the frequency of anatomical variation in the arrangement of the coronary arteries is lower in the pig than in humans.
ER  -